Tramadol Contramid OAD

We are developing a once-daily formulation of tramadol. Tramadol is a non-scheduled, centrally acting analgesic for the treatment of pain. It is currently available in the United States for the treatment of moderate to moderately severe pain as an immediate release formulation, typically requiring four to six doses per day, and as a recently launched once-daily formulation. In Europe, tramadol is currently available as immediate release, twice-daily and once-daily formulations for the treatment of moderate to severe pain.

Our once-daily tramadol product consists of a dual matrix delivery system designed to provide both rapid and sustained drug release to maintain blood levels within the therapeutic range providing a full 24 hours of pain relief. We believe that maintaining drug concentrations within the therapeutic range has the advantage of fewer and less severe side effects while maintaining efficacy.

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